Lectins in drug delivery to the oral cavity

Lectins in drug delivery to the oral cavity by Paul Kwasi Kankam Nantwi Download PDF EPUB FB2

Lectins for drug delivery within the oral cavity. The use of lectins for drug delivery within the oral cavity is still an undeveloped area. To confer a therapeutic advantage, lectin-containing delivery systems would have to: • bind rapidly and be retained for extended periods and/or; • locate and target a specific location; •Cited by: Lectin-containing delivery systems are a potential innovation for targeted and prolonged therapy within the oral cavity, but considerations such as toxicity and cost will need to be addressed before their routine use becomes a by: Lectins can also be used in drug delivery to the buccal cavity and also to the nasal mucosa as this type of bioadhesive system enhances the contact time between the drug Author: John D Smart.

In nature lectins are implicated in cell recognition and adhesion processes, and have been described as "second generation" mucoadhesives. The aim of this project was to identify lectins that could be incorporated into dosage forms to allow their retention within the oral cavity.

This would allow prolonged localised drug delivery. TY - JOUR. T1 - Lectins in drug delivery to the oral cavity, in vitro toxicity studies. AU - Smart, John. AU - Banchonglikitkul, C. AU - Gibbs, by: 3. The delivery of therapeutic agents to, or via, the oral cavity is limited by the efficient removal mechanisms that exist in this area.

Lectins are proteins or glycoproteins that bind to specific sugar residues, and can, therefore, interact with the glycoconjugates present on cell surfaces or salivary mucins.

The delivery of therapeutic agents to, or via, the oral cavity is limited by the efficient removal mechanisms that exist in this area. Lectins are proteins or glycoproteins that bind to specific sugar residues, and can, therefore, interact with the glycoconjugates present on cell surfaces or salivary by: Lectins in drug delivery to the oral cavity.

(Thesis) Nantwi PKK. Publisher: University of Portsmouth [] Metadata Source: The British Library Type: Thesis. Abstract. Highlight Terms No biological terms identified No abstract supplied. Menu Formats. Abstract; Thesis at. Drug Delivery to the Oral Cavity PDF Drug Delivery to the Oral Cavity PDF Free Download Drug Delivery to the Oral Cavity PDF Drug Delivery to the Oral Cavity Ebook Content The oral cavity (OC) and its highly permeable mucosal tissues have been taken advantage of for decades as a site of absorption for delivery.

New strategies have been developed for drug delivery control and for directing these systems to the targeted site improving the therapy.

In this commentary, the lectins are briefly reviewed; their fundamentals and the proposed applications as ligands in nanostructured drug delivery Cited by: 1.

The unique carbohydrate specificities of plant lectins can facilitate mucoadhesion and cytoadhesion of drugs. As immunostimulatory molecules with an adjuvant effect plant lectins can also be employed in vaccine by: Recently, lectin-based second-generation bioadhesives have attracted considerable interests for oral drug delivery.

It has been found that lectin binding on human buccal cells occurred within 20 second and was not detached by saliva flushing (33).Cited by: Lectins in drug delivery to the oral cavity, in vitro toxicity studies By John Smart, C.

Banchonglikitkul, R.V. Gibbs, S.J. Donovan and D.J. Cook Topics: B Pharmacology and Therapeutics, A Clinical Dentistry. Vaginal Mucoadhesive Drug Delivery Systems. The vagina is a fibrovascular tube connecting the uterus to the outer surface of the body.

The vaginal epithelium consists of a stratified squamous epithelium and lamina propia. Dosage forms used for vaginal route are solutions, gels, suspensions, suppositories, creams.

Anatomy and Physiology of the Oral Cavity. Local Diseases of the Oral Cavity. Permeability of the Buccal and Gingival Mucosa. Drug Delivery Systems for the Oral Cavity. Formulations. Conclusions. ReferencesCited by: 4. Physiological barriers for oral transmucosal drug delivery The environment of the oral cavity presents some significant challenges for systemic drug delivery.

The drug needs to be released from the formulation to the delivery site (e.g. buccal or sublingual area) and pass through the mucosal layers to enter the systemic circulation. Smart JD () Lectin-mediated drug delivery in the oral cavity.

Adv Drug Deliv Rev – PubMed CrossRef Google Scholar Stewart K, Brown OA, Morelli AE et al () Uptake of α-(L)-iduronidase produced by retrovirally transduced fibroblasts into neuronal and glial cells in : Rajesh K.

Gupta, Anita Gupta. Lectins from green salads, fruits, spices, seeds, dry cereals and nuts (even after roasting) showed activity of potentially toxic lectins. Some of these lectins interact with serum or salivary components and bacteria from the oral cavity (Gibbons & Dankers, ).

Amply referenced with over bibliographic citations, and illustrated with more than drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an 5/5(1).

Free Download of Design of Controlled Release Drug Delivery Systems pdf e-book. Edited By Xiaoling Li & Bhaskara R. Jasti. To Download this book click on the following image or link:Author: Pharmatech.

In recent years, the emphasis in drug development has been the design of new delivery systems rather than new drugs. It is the aim of innovative pharmaceutical scientists to design the new dosage forms to overcome the body's barrier mechanisms which have specifically evolved to exclude foreign book provides an integrated approach to the study of drug 4/5(1).

Giannola LI, Sutera FM, De Caro V () Physical methods to promote drug delivery on mucosal tissues of the oral cavity. Expert Opin Drug Deliv 10(10)– doi: / CrossRef PubMed Google ScholarCited by: The Importance of Oral and Dental Health in College Students.

This note covers the following topics: Bacterial Diversity in the Oral Cavity, Oral-Systemic Link, Tooth Brushing, Flossing, Common Oral Hygiene Mistakes, Oral Cavity and Oropharyngeal Cancers, Oral Cavity and Oropharyngeal Cancer, Acute Dental Trauma, Controlling Bleeding and Swelling, Complications of Oral.

A Review on Oral Mucosal Drug Delivery System Rakesh Hooda*, Mohit Tripathi and Prof. Kiran Kapoor Submitted Accepted for publication Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery.

The acid hydrolysis and first pass effects can be. [Drugs for use in the mouth cavity] The effect of hydrocortisone on the organ cultures of normal and pathologic mucous membranes of human oral cavity.

Török O, Bánóczy J. Acta Morphol Acad Sci Hung, 20(1) Lectin-mediated drug delivery in the oral cavity. Smart JD. Adv Drug Deliv Rev, 56(4), Author: Kircher W. ISBN: OCLC Number: Description: xix, pages: illustrations ; 24 cm.

Series Title: Drugs and the pharmaceutical sciences. However, the oral cavity can also be used to achieve the systemic delivery of a drug, i.e., oral transmucosal delivery. As described in Chapter 7, the peroral (i.e., via the gastrointestinal [GI] tract) route remains the preferred route for the administration of therapeutic agents because of its low cost, ease of administration and high level Author: Anya M Hillery, Kinam Park.

By Kalliopi Dodou. In this month’s science article, Kalliopi Dodou examines the pharmaceutics behind buccal and sublingual drug delivery and looks at new developments in this area Oral administration of medicines still enjoys a hallowed place in drug delivery systems and, unsurprisingly, still takes the lion’s share of the pharmaceuticals marketplace.

Drug Delivery to the Oral Cavity: Molecules to Market With contributions from recognized authorities in industry, academia, and government, this reference presents the state-of-the-art in the testing, formulation, and clinical evaluation of intraoral drug delivery products-summarizing intraoral dosage forms in various stages of research, as well as products currently on the market.

GUPTA et al: MANNAN BINDING LECTINS IN DRUG AND GENE DELIVERY Serum MBP, or MBL, is a Ca2+-dependent lectin that belongs to family of animal lectins isolated from liver and serum of rabbits, humans and rodents.

Serum MBP is specific for mannose or N-acetylglucosamine (GlcNAc), and contains both a collagen-like domain and a CRD (Fig. 2B). Oral administration is the most commonly used and readily accepted form of drug delivery; however, it is find that many drugs are difficult to attain enough bioavailability when administered via this route.

Polymeric micelles (PMs) can overcome some limitations of the oral delivery acting as carriers able to enhance drug absorption, by providing (1) protection of the loaded drug Cited by: In it, the authors cite a study from showing that 30% of fresh and processed foods contain lectins.

Lectins from green salads, fruits, spices, seeds, dry cereals and nuts showed lectin activity, and some of them interact with blood serum or saliva and bacteria from the oral cavity. DeepDyve is the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Oral health is defined as “being free of chronic mouth and facial pain, oral and throat cancer, oral sores, birth defects such as cleft lip and palate, peri-odontal (gum) disease, tooth decay and tooth loss, and other diseases and disorders that affect the mouth and oral cavity” (World Health Organization [WHO], a).File Size: 1MB.